Neoplaether, a new cytotoxic and antifungal endophyte metabolite fromNeoplaconema napellumIFB-E016

Structure and total synthesis of aspernigerin: a novel cytotoxic endophyte metabolite.

Aspernigerin (1), a novel cytotoxic alkaloid consisting of an unprecedented structural framework has been isolated from the extract of a culture of Aspergillus niger IFB-E003, an endophyte in Cyndon dactylon. Its structure was elucidated on the basis of comprehensive NMR spectral analysis and confirmed by single-crystal X-ray analysis. Aspernigerin (1) has been shown to be cytotoxic to the tumo...

antibacterial, antifungal and cytotoxic evaluation of some new quinazolinone derivatives

quinazolinone ring system is renown because of its wide spectrum of pharmacological activities due to various substitutions on this ring system. in this study, the minimum inhibitory concentration of the synthesized compounds in our laboratory was determined by micro dilution alamar blue ® assay against six strains of bacteria (three gram-positive and three gram-negative) and three strains of f...

Antibiotics from basidiomycetes. X. Scorodonin, a new antibacterial and antifungal metabolite from Marasmius scorodonius (Fr.) Fr.

Scorodonin (1), a novel biologically active metabolite, was isolated from submerged cultures of the mushroom Marasmius scorodonius (FR.) FR. Its structure has been determined by chemical and physical methods. The antibiotic inhibits the growth of bacteria, yeasts, and filamentous fungi. In cells of the ascitic form of EHRLICH carcinoma the incorporation of thymidine and uridine into DNA and RNA...

a new algorithm and software of individual life insurance and annuity computation

چکیده ندارد.

synthesis and antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives